Functional Genomics in Trypanosomes: Using RNA Interference to Assign Gene Function and Validate Drug Targets in Tropical Disease Agents
نویسندگان
چکیده
Trypanosomes are unicellular protozoa and members of the order kinetoplastida, a highly divergent branch of the eukaryota which probably separated from the mammalian lineage ~3 x 10 years ago. Pathogenic trypanosomatids include the causative agents for Chagas’ disease or South American trypanosomiasis and Kala Azar or Leishmaniasis. They are equally divergent from the Apicomplexan protozoa that cause Malaria, Toxoplasmosis and Tularemia.
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